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KMID : 0363020070370040743
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Journal of Korean Academy of Periodontology
2007 Volume.37 No. 4 p.743 ~ p.753
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The Gingival Tissue Levels of Bone Resorptive Mediators in Human Chronic Periodontitis with Type 2 Diabetes Mellitus
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Kim Mi-Jeong
Park Jin-Woo
Suh Jo-Young
Lee Jae-Mok
Ryu Sang-Ho
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Abstract
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Purpose: The purposes of this study were to compare and quantify the expression of MMP-3, and IL-6 in the gingival tissues of patients with diabetes mellitus and healthy adults with chronic periodontitis.
Material and methods: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient’s systemic condition & clinical criteria of gingiva, each gingival sample was devided into three groups. Group 1(n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2(n=8) is inflamed gingiva from patients with chronic periodontitis. Group 3(n=8) is inflamed gingiva from patients with chronic periodontitis associated with type 2 DM. Tissue samples were prepared and analyzed by Westernblotting. The quantification of MMP-3, and IL-6 were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test.
Results: 1. The expression levels of MMP-3 were shown highest in group 3 compared to group 1 and 2, and It showed increasing tendency in group 2 and 3. 2. The expressions of and IL-6 were shown increasing tendency in group 2 and 3, and It was highest in group 3. 3. As expressions of MMP-3 were increased, and IL-6 expressions showed increasing tendency in group 3 than group1 and 2, although there were no proportional relationship.
Conclusion: This study demonstrated that the expression levels of MMP-3, and IL-6 will be inflammatory markers of periodonta linflamed tissue and DM. It can be assumed that MMP-3 affect to expressions of and IL-6 in progression of periodontal inflammation with alveolar bone resorption to type 2 DM.
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KEYWORD
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Chronic periodontitis, diabetes mellitus, bone resorption factor
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